{"symbol":"CTSD","synonyms":["CPSD","CLN10","HEL-S-130P"],"name":"cathepsin D","description":"This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer\u0027s disease. [provided by RefSeq, Nov 2015]","ncbiEntrezGeneId":1509,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1509","proteins":[{"symbol":"CATD_HUMAN","href":"/api/1.0/protein/CATD_HUMAN"}],"hgncRootFamilies":[{"name":"Cathepsins (CTS)","href":"/api/1.0/gene_family/Cathepsins+%28CTS%29"}]}