{"symbol":"CUL1","synonyms":[],"name":"cullin 1","description":"Enables ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of canonical NF-kappaB signal transduction; and protein K48-linked ubiquitination. Located in plasma membrane. Part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":8454,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8454","proteins":[{"symbol":"CUL1_HUMAN","href":"/api/1.0/protein/CUL1_HUMAN"}],"hgncRootFamilies":[]}