{"symbol":"CUL4B","synonyms":["CUL-4B","MRXS15","MRXHF2","MRXSC","SFM2"],"name":"cullin 4B","description":"This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8450,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8450","proteins":[{"symbol":"CUL4B_HUMAN","href":"/api/1.0/protein/CUL4B_HUMAN"}],"hgncRootFamilies":[]}