{"symbol":"DAB2","synonyms":["DOC-2"],"name":"Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)","description":"This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]","ncbiEntrezGeneId":1601,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1601","proteins":[{"symbol":"DAB2_HUMAN","href":"/api/1.0/protein/DAB2_HUMAN"}],"hgncRootFamilies":[]}