{"symbol":"DAD1","synonyms":["OST2"],"name":"defender against cell death 1","description":"DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line.  The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis.  DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":1603,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1603","proteins":[{"symbol":"DAD1_HUMAN","href":"/api/1.0/protein/DAD1_HUMAN"}],"hgncRootFamilies":[{"name":"Oligosaccharyltransferase complex","href":"/api/1.0/gene_family/Oligosaccharyltransferase+complex"}]}