{"symbol":"DCN","synonyms":["PGS2","SLRR1B","PG40","PGII","DSPG2","CSCD"],"name":"decorin","description":"This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]","ncbiEntrezGeneId":1634,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1634","proteins":[{"symbol":"PGS2_HUMAN","href":"/api/1.0/protein/PGS2_HUMAN"}],"hgncRootFamilies":[{"name":"Proteoglycans","href":"/api/1.0/gene_family/Proteoglycans"}]}