{"symbol":"DCTN3","synonyms":["DCTN-22","DCTN22"],"name":"dynactin 3 (p22)","description":"This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]","ncbiEntrezGeneId":11258,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/11258","proteins":[{"symbol":"DCTN3_HUMAN","href":"/api/1.0/protein/DCTN3_HUMAN"}],"hgncRootFamilies":[{"name":"Dynactin (DCTN)","href":"/api/1.0/gene_family/Dynactin+%28DCTN%29"}]}