{"symbol":"DDX5","synonyms":["HUMP68","G17P1","HLR1"],"name":"DEAD (Asp-Glu-Ala-Asp) box helicase 5","description":"This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]","ncbiEntrezGeneId":1655,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1655","proteins":[{"symbol":"DDX5_HUMAN","href":"/api/1.0/protein/DDX5_HUMAN"}],"hgncRootFamilies":[{"name":"DEAD box polypeptides (DDX)","href":"/api/1.0/gene_family/DEAD+box+polypeptides+%28DDX%29"}]}