{"symbol":"DDX58","synonyms":["RIG-I","RIGI","RLR-1","SGMRT2"],"name":"DEAD (Asp-Glu-Ala-Asp) box polypeptide 58","description":"DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]","ncbiEntrezGeneId":23586,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23586","proteins":[{"symbol":"DDX58_HUMAN","href":"/api/1.0/protein/DDX58_HUMAN"}],"hgncRootFamilies":[{"name":"DEAD box polypeptides (DDX)","href":"/api/1.0/gene_family/DEAD+box+polypeptides+%28DDX%29"}]}