{"symbol":"DEFB114","synonyms":["DEFB14","DEFB-14"],"name":"defensin, beta 114","description":"Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. The protein encoded by this gene is a beta-defensin with antimicrobial activity against E. coli, S. aureus, and C. albicans. The encoded protein also binds and neutralizes lipopolysaccharide (LPS), a factor involved in inflammatory diseases and male reproductive issues. [provided by RefSeq, Nov 2014]","ncbiEntrezGeneId":245928,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/245928","proteins":[{"symbol":"DB114_HUMAN","href":"/api/1.0/protein/DB114_HUMAN"}],"hgncRootFamilies":[{"name":"Defensins","href":"/api/1.0/gene_family/Defensins"}]}