{"symbol":"DEGS1","synonyms":["MIG15","DEGS-1","DEGS","DES-1","FADS7","DES1"],"name":"delta(4)-desaturase, sphingolipid 1","description":"This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010]","ncbiEntrezGeneId":8560,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8560","proteins":[{"symbol":"DEGS1_HUMAN","href":"/api/1.0/protein/DEGS1_HUMAN"}],"hgncRootFamilies":[{"name":"Fatty acid desaturases (FADS)","href":"/api/1.0/gene_family/Fatty+acid+desaturases+%28FADS%29"}]}