{"symbol":"DLG3","synonyms":["MRX90","NEDLG","XLMR","MRX","SAP102","PPP1R82"],"name":"discs, large homolog 3 (Drosophila)","description":"This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]","ncbiEntrezGeneId":1741,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1741","proteins":[{"symbol":"DLG3_HUMAN","href":"/api/1.0/protein/DLG3_HUMAN"}],"hgncRootFamilies":[{"name":"Protein phosphatase 1 regulatory subunits (PPP1R)","href":"/api/1.0/gene_family/Protein+phosphatase+1+regulatory+subunits+%28PPP1R%29"},{"name":"X-linked mental retardation","href":"/api/1.0/gene_family/X-linked+mental+retardation"},{"name":"Membrane-associated guanylate kinases","href":"/api/1.0/gene_family/Membrane-associated+guanylate+kinases"}]}