{"symbol":"DNTT","synonyms":["TDT"],"name":"DNA nucleotidylexotransferase","description":"This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3\u0027-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":1791,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1791","proteins":[{"symbol":"TDT_HUMAN","href":"/api/1.0/protein/TDT_HUMAN"}],"hgncRootFamilies":[{"name":"Polymerases, DNA-directed (POL)","href":"/api/1.0/gene_family/Polymerases%2C+DNA-directed+%28POL%29"}]}