{"symbol":"DOCK3","synonyms":["PBP","MOCA"],"name":"dedicator of cytokinesis 3","description":"This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]","ncbiEntrezGeneId":1795,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1795","proteins":[{"symbol":"DOCK3_HUMAN","href":"/api/1.0/protein/DOCK3_HUMAN"}],"hgncRootFamilies":[]}