{"symbol":"DPH5","synonyms":["CGI-30","NPD015","HSPC143","AD-018"],"name":"diphthamide biosynthesis 5","description":"This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":51611,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51611","proteins":[{"symbol":"DPH5_HUMAN","href":"/api/1.0/protein/DPH5_HUMAN"}],"hgncRootFamilies":[]}