{"symbol":"DPP4","synonyms":["ADCP2","DPPIV","TP103","ADABP","CD26"],"name":"dipeptidyl-peptidase 4","description":"The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020]","ncbiEntrezGeneId":1803,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1803","proteins":[{"symbol":"DPP4_HUMAN","href":"/api/1.0/protein/DPP4_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}