{"symbol":"DPYD","synonyms":["DHPDHASE","DHP","DPD"],"name":"dihydropyrimidine dehydrogenase","description":"The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]","ncbiEntrezGeneId":1806,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1806","proteins":[{"symbol":"DPYD_HUMAN","href":"/api/1.0/protein/DPYD_HUMAN"}],"hgncRootFamilies":[]}