{"symbol":"DPYSL2","synonyms":["CRMP-2","DHPRP2","ULIP-2","CRMP2","N2A3","DRP2","ULIP2"],"name":"dihydropyrimidinase-like 2","description":"This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer\u0027s disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]","ncbiEntrezGeneId":1808,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1808","proteins":[{"symbol":"DPYL2_HUMAN","href":"/api/1.0/protein/DPYL2_HUMAN"}],"hgncRootFamilies":[]}