{"symbol":"DRAP1","synonyms":["NC2-ALPHA"],"name":"DR1-associated protein 1 (negative cofactor 2 alpha)","description":"Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans.  Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10589,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10589","proteins":[{"symbol":"NC2A_HUMAN","href":"/api/1.0/protein/NC2A_HUMAN"}],"hgncRootFamilies":[]}