{"symbol":"DSC2","synonyms":["DSC3","ARVD11","DGII/III","CDHF2","DG2"],"name":"desmocollin 2","description":"This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]","ncbiEntrezGeneId":1824,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1824","proteins":[{"symbol":"DSC2_HUMAN","href":"/api/1.0/protein/DSC2_HUMAN"}],"hgncRootFamilies":[{"name":"Cadherins","href":"/api/1.0/gene_family/Cadherins"}]}