{"symbol":"DSG1","synonyms":["CDHF4","DSG","PPKS1","EPKHE","DG1","SPPK1","EPKHIA"],"name":"desmoglein 1","description":"This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]","ncbiEntrezGeneId":1828,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1828","proteins":[{"symbol":"DSG1_HUMAN","href":"/api/1.0/protein/DSG1_HUMAN"}],"hgncRootFamilies":[{"name":"Cadherins","href":"/api/1.0/gene_family/Cadherins"}]}