{"symbol":"DSG3","synonyms":["CDHF6","PVA"],"name":"desmoglein 3","description":"This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. [provided by RefSeq, Jan 2016]","ncbiEntrezGeneId":1830,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1830","proteins":[{"symbol":"DSG3_HUMAN","href":"/api/1.0/protein/DSG3_HUMAN"}],"hgncRootFamilies":[{"name":"Cadherins","href":"/api/1.0/gene_family/Cadherins"}]}