{"symbol":"DUOX1","synonyms":["LNOX1","THOX1","NOXEF1"],"name":"dual oxidase 1","description":"The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]","ncbiEntrezGeneId":53905,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/53905","proteins":[{"symbol":"DUOX1_HUMAN","href":"/api/1.0/protein/DUOX1_HUMAN"}],"hgncRootFamilies":[{"name":"EF-hand domain containing","href":"/api/1.0/gene_family/EF-hand+domain+containing"}]}