{"symbol":"E4F1","synonyms":["E4F"],"name":"E4F transcription factor 1","description":"The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]","ncbiEntrezGeneId":1877,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1877","proteins":[{"symbol":"E4F1_HUMAN","href":"/api/1.0/protein/E4F1_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}