{"symbol":"ECH1","synonyms":["HPXEL"],"name":"enoyl CoA hydratase 1, peroxisomal","description":"This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":1891,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1891","proteins":[{"symbol":"ECH1_HUMAN","href":"/api/1.0/protein/ECH1_HUMAN"}],"hgncRootFamilies":[]}