{"symbol":"ECT2","synonyms":["ARHGEF31"],"name":"epithelial cell transforming 2","description":"The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]","ncbiEntrezGeneId":1894,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1894","proteins":[{"symbol":"ECT2_HUMAN","href":"/api/1.0/protein/ECT2_HUMAN"}],"hgncRootFamilies":[{"name":"Rho guanine nucleotide exchange factors (ARHGEF)","href":"/api/1.0/gene_family/Rho+guanine+nucleotide+exchange+factors+%28ARHGEF%29"}]}