{"symbol":"EDA","synonyms":["EDA-A2","EDA2","EDA1","ODT1","ED1","XHED","STHAGX1","HED","EDA-A1","HED1","TNLG7C","ECTD1","XLHED","ED1-A2","ED1-A1"],"name":"ectodysplasin A","description":"The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":1896,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1896","proteins":[{"symbol":"EDA_HUMAN","href":"/api/1.0/protein/EDA_HUMAN"}],"hgncRootFamilies":[{"name":"Tumor necrosis factor (ligand) superfamily (TNFSF)","href":"/api/1.0/gene_family/Tumor+necrosis+factor+%28ligand%29+superfamily+%28TNFSF%29"}]}