{"symbol":"EDN2","synonyms":["ET2","PPET2","ET-2"],"name":"endothelin 2","description":"This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]","ncbiEntrezGeneId":1907,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1907","proteins":[{"symbol":"EDN2_HUMAN","href":"/api/1.0/protein/EDN2_HUMAN"}],"hgncRootFamilies":[{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"}]}