{"symbol":"EDNRA","synonyms":["ETRA","ETAR","MFDA","HET-AR","ET-A","ETA","ETA-R"],"name":"endothelin receptor type A","description":"This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]","ncbiEntrezGeneId":1909,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1909","proteins":[{"symbol":"EDNRA_HUMAN","href":"/api/1.0/protein/EDNRA_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}