{"symbol":"EEF1E1","synonyms":["AIMP3"],"name":"eukaryotic translation elongation factor 1 epsilon 1","description":"This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]","ncbiEntrezGeneId":9521,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9521","proteins":[{"symbol":"MCA3_HUMAN","href":"/api/1.0/protein/MCA3_HUMAN"}],"hgncRootFamilies":[]}