{"symbol":"EFNA2","synonyms":["LERK-6","ELF-1","LERK6","HEK7-L","EPLG6"],"name":"ephrin-A2","description":"This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":1943,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1943","proteins":[{"symbol":"EFNA2_HUMAN","href":"/api/1.0/protein/EFNA2_HUMAN"}],"hgncRootFamilies":[{"name":"Ephrins (EFN)","href":"/api/1.0/gene_family/Ephrins+%28EFN%29"}]}