{"symbol":"EIF2B3","synonyms":["EIF2BGAMMA"],"name":"eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa","description":"The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]","ncbiEntrezGeneId":8891,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8891","proteins":[{"symbol":"EI2BG_HUMAN","href":"/api/1.0/protein/EI2BG_HUMAN"}],"hgncRootFamilies":[]}