{"symbol":"EIF2S1","synonyms":["EIF2","EIF-2ALPHA","EIF2A","EIF-2","EIF-2A"],"name":"eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa","description":"The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]","ncbiEntrezGeneId":1965,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1965","proteins":[{"symbol":"IF2A_HUMAN","href":"/api/1.0/protein/IF2A_HUMAN"}],"hgncRootFamilies":[]}