{"symbol":"EIF3D","synonyms":["EIF3S7","EIF3-ZETA","EIF3-P66"],"name":"eukaryotic translation initiation factor 3, subunit D","description":"Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8664,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8664","proteins":[{"symbol":"EIF3D_HUMAN","href":"/api/1.0/protein/EIF3D_HUMAN"}],"hgncRootFamilies":[]}