{"symbol":"EIF4E","synonyms":["EIF4EL1","eIF-4E","EIF4E1","AUTS19"],"name":"eukaryotic translation initiation factor 4E","description":"The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5\u0027 end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5\u0027-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]","ncbiEntrezGeneId":1977,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1977","proteins":[{"symbol":"IF4E_HUMAN","href":"/api/1.0/protein/IF4E_HUMAN"}],"hgncRootFamilies":[]}