{"symbol":"EIF4G1","synonyms":["EIF-4G1","PARK18","EIF4G","P220","EIF4GI"],"name":"eukaryotic translation initiation factor 4 gamma, 1","description":"The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5\u0027-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]","ncbiEntrezGeneId":1981,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1981","proteins":[{"symbol":"IF4G1_HUMAN","href":"/api/1.0/protein/IF4G1_HUMAN"}],"hgncRootFamilies":[{"name":"Parkinson disease associated genes (PARK)","href":"/api/1.0/gene_family/Parkinson+disease+associated+genes+%28PARK%29"}]}