{"symbol":"ELAC2","synonyms":["COXPD17","ELC2"],"name":"elaC ribonuclease Z 2","description":"The protein encoded by this gene has a C-terminal domain with tRNA 3\u0026#8242; processing endoribonuclease activity, which catalyzes the removal of the 3\u0027 trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]","ncbiEntrezGeneId":60528,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/60528","proteins":[{"symbol":"RNZ2_HUMAN","href":"/api/1.0/protein/RNZ2_HUMAN"}],"hgncRootFamilies":[]}