{"symbol":"ENDOU","synonyms":["PP11","PRSS26"],"name":"endonuclease, polyU-specific","description":"This gene encodes a protein with endoribonuclease activity that binds polyuridine-enriched single-stranded RNA. This gene was initially characterized based on its high expression in placenta but was mischaracterized as a serine protease. In mouse, this gene promotes tolerance to self-antigens by regulating B cell activation-induced cell death (AICD). The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2020]","ncbiEntrezGeneId":8909,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8909","proteins":[{"symbol":"ENDOU_HUMAN","href":"/api/1.0/protein/ENDOU_HUMAN"}],"hgncRootFamilies":[{"name":"Proteases, serine (PRSS)","href":"/api/1.0/gene_family/Proteases%2C+serine+%28PRSS%29"}]}