{"symbol":"ENO1","synonyms":["MPB1","HEL-S-17","NNE","PPH","ENO1L1"],"name":"enolase 1, (alpha)","description":"This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]","ncbiEntrezGeneId":2023,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2023","proteins":[{"symbol":"ENOA_HUMAN","href":"/api/1.0/protein/ENOA_HUMAN"}],"hgncRootFamilies":[]}