{"symbol":"EOMES","synonyms":["TBR2"],"name":"eomesodermin","description":"This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]","ncbiEntrezGeneId":8320,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8320","proteins":[{"symbol":"EOMES_HUMAN","href":"/api/1.0/protein/EOMES_HUMAN"}],"hgncRootFamilies":[{"name":"T-boxes (TBX)","href":"/api/1.0/gene_family/T-boxes+%28TBX%29"}]}