{"symbol":"EP300","synonyms":["RSTS2","P300","KAT3B"],"name":"E1A binding protein p300","description":"This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":2033,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2033","proteins":[{"symbol":"EP300_HUMAN","href":"/api/1.0/protein/EP300_HUMAN"}],"hgncRootFamilies":[{"name":"Chromatin-modifying enzymes","href":"/api/1.0/gene_family/Chromatin-modifying+enzymes"}]}