{"symbol":"EPHA8","synonyms":["EEK","EK3","HEK3"],"name":"EPH receptor A8","description":"This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":2046,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2046","proteins":[{"symbol":"EPHA8_HUMAN","href":"/api/1.0/protein/EPHA8_HUMAN"}],"hgncRootFamilies":[{"name":"Fibronectin type III domain containing","href":"/api/1.0/gene_family/Fibronectin+type+III+domain+containing"},{"name":"Sterile alpha motif (SAM) domain containing (SAMD)","href":"/api/1.0/gene_family/Sterile+alpha+motif+%28SAM%29+domain+containing+%28SAMD%29"},{"name":"Receptor kinases","href":"/api/1.0/gene_family/Receptor+kinases"}]}