{"symbol":"EPHB3","synonyms":["ETK2","TYRO6","EK2","HEK2"],"name":"EPH receptor B3","description":"Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]","ncbiEntrezGeneId":2049,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2049","proteins":[{"symbol":"EPHB3_HUMAN","href":"/api/1.0/protein/EPHB3_HUMAN"}],"hgncRootFamilies":[{"name":"Receptor kinases","href":"/api/1.0/gene_family/Receptor+kinases"},{"name":"Sterile alpha motif (SAM) domain containing (SAMD)","href":"/api/1.0/gene_family/Sterile+alpha+motif+%28SAM%29+domain+containing+%28SAMD%29"},{"name":"Fibronectin type III domain containing","href":"/api/1.0/gene_family/Fibronectin+type+III+domain+containing"}]}