{"symbol":"ERBB4","synonyms":["ALS19","HER4","P180ERBB4"],"name":"erb-b2 receptor tyrosine kinase 4","description":"This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":2066,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2066","proteins":[{"symbol":"ERBB4_HUMAN","href":"/api/1.0/protein/ERBB4_HUMAN"}],"hgncRootFamilies":[{"name":"Receptor kinases","href":"/api/1.0/gene_family/Receptor+kinases"}]}