{"symbol":"ESX1","synonyms":["ESX1L","ESXR1"],"name":"ESX homeobox 1","description":"This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010]","ncbiEntrezGeneId":80712,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/80712","proteins":[{"symbol":"ESX1_HUMAN","href":"/api/1.0/protein/ESX1_HUMAN"}],"hgncRootFamilies":[{"name":"Homeoboxes","href":"/api/1.0/gene_family/Homeoboxes"}]}