{"symbol":"FANCL","synonyms":["POG","FAAP43","PHF9"],"name":"Fanconi anemia, complementation group L","description":"This gene encodes a ubiquitin ligase that is a member of the Fanconi anemia complementation group (FANC). Members of this group are related by their assembly into a common nuclear protein complex rather than by sequence similarity. This gene encodes the protein for complementation group L that mediates monoubiquitination of FANCD2 as well as FANCI. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2018]","ncbiEntrezGeneId":55120,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55120","proteins":[{"symbol":"FANCL_HUMAN","href":"/api/1.0/protein/FANCL_HUMAN"}],"hgncRootFamilies":[{"name":"Fanconi anemia, complementation groups (FANC)","href":"/api/1.0/gene_family/Fanconi+anemia%2C+complementation+groups+%28FANC%29"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}