{"symbol":"FAT1","synonyms":["CDHF7","HFAT1","CDHR8","ME5"],"name":"FAT atypical cadherin 1","description":"This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":2195,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2195","proteins":[{"symbol":"FAT1_HUMAN","href":"/api/1.0/protein/FAT1_HUMAN"}],"hgncRootFamilies":[{"name":"Cadherins","href":"/api/1.0/gene_family/Cadherins"}]}