{"symbol":"FBXL2","synonyms":["FBL2","FBL3"],"name":"F-box and leucine-rich repeat protein 2","description":"This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]","ncbiEntrezGeneId":25827,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/25827","proteins":[{"symbol":"FBXL2_HUMAN","href":"/api/1.0/protein/FBXL2_HUMAN"}],"hgncRootFamilies":[{"name":"F-boxes (FBX)","href":"/api/1.0/gene_family/F-boxes+%28FBX%29"}]}