{"symbol":"FBXO2","synonyms":["Fbs1","OCP1","FBG1","FBX2","NFB42"],"name":"F-box protein 2","description":"This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":26232,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/26232","proteins":[{"symbol":"FBX2_HUMAN","href":"/api/1.0/protein/FBX2_HUMAN"}],"hgncRootFamilies":[{"name":"F-boxes (FBX)","href":"/api/1.0/gene_family/F-boxes+%28FBX%29"}]}