{"symbol":"FBXO45","synonyms":["FBX45"],"name":"F-box protein 45","description":"Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]","ncbiEntrezGeneId":200933,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/200933","proteins":[{"symbol":"FBSP1_HUMAN","href":"/api/1.0/protein/FBSP1_HUMAN"}],"hgncRootFamilies":[{"name":"F-boxes (FBX)","href":"/api/1.0/gene_family/F-boxes+%28FBX%29"}]}